Center for Clinical Pharmacology

Kristine Griffett, Ph.D., Assistant Professor

Kristine Griffett HeadshotKristine Griffett Ph.D. is an Assistant Professor of Pharmacology at St. Louis College of Pharmacy within the Center for Clinical Pharmacology.  Prior to joining STLCOP, Dr. Griffett was a Research Assistant Professor at Saint Louis University School of Medicine in the Department of Pharmacology and Physiology under the guidance of Dr. Thomas Burris.  She has also held NIDDK NRSA-funded Postdoctoral Fellow position at Saint Louis University and a Research Associate position at the Scripps Research Institute in Jupiter, FL.   Prior to this, Dr. Griffett obtained her Ph.D. in Developmental Genetics at the University of South Florida in the Department of Cell Biology, Microbiology, and Molecular Biology.


Dr. Griffett’s current research focuses on nuclear hormone receptor physiology and pharmacology for developing targeted therapeutics for cardio-metabolic diseases.  Her current and previous funded work focuses on targeting the Liver X Receptors with novel tissue-specific compounds to treat fatty liver diseases (NAFLD and NASH) and atherosclerosis.  Other research projects are identifying role of the nuclear receptor REV-ERB in the development of fibrosis and inflammatory response during the progression of liver disease, elucidating the natural ligands of orphan receptors involved in proliferation and stemness in glioblastoma, and characterizing novel scaffolds of drugs targeting LXR for Alzheimer’s Disease, Inflammation, and COPD.  Dr. Griffett is currently funded by the American Heart Association.