Center for Clinical Pharmacology

Evan Kharasch, Director of the Center

Dr. Evan Kharasch, directorEvan D. Kharasch, M.D., Ph.D., is the Russell and Mary Shelden Professor of Anesthesiology and director of the Division of Clinical and Translational Research in the Department of Anesthesiology at Washington University School of Medicine in St. Louis. He is also a professor in the Department of Biochemistry and Molecular Biophysics and holds appointments in the Washington University Pain Center and Siteman Cancer Center. He joined Washington University in St. Louis in 2005.

Kharasch leads an active research program in basic, translational and clinical pharmacology, and he is a practicing anesthesiologist. His research focuses on anesthetic and analgesic drugs, drugs of abuse, and addiction therapies, towards the goal of understanding hepatic and extra-hepatic drug metabolism and drug transport (hepatic, renal, intestinal, and the blood-brain barrier), pharmacokinetics, pharmacodynamics, pharmacogenetics, toxicity, drug interactions, and variability in patient response. These are directed towards optimizing drug disposition, drug safety, clinical effectiveness, and patient satisfaction.

His research also focuses on the development and application of novel noninvasive biomarkers and tests. A major area of focus is noninvasive biomarkers for population screening and differential diagnosis of kidney cancer. He holds patents for that technology, which is currently undergoing commercialization.

Kharasch is the author of more than 230 research papers, as well as numerous book chapters, and is the editor of two major textbooks on anesthetic pharmacology. His research has been continuously NIH-funded for two decades. He is an elected member of the Institute of Medicine of the National Academies.

Kharasch served as the vice chancellor for research at Washington University in St. Louis from 2009 to 2014, where he was responsible for overseeing research infrastructure and related administrative, policy and operational activities of the University. This included the University’s Office of Technology Management, which is responsible for the protection and commercialization of University intellectual property. He was the institutional official for human studies research and animal research. He also led a University-wide initiative in research innovation and entrepreneurship to expand Washington University’s research culture in research commercialization.

Kharasch earned his Bachelor of Science, Doctor of Medicine, and Doctor of Philosophy in Pharmacology from Northwestern University and received anesthesiology training at the University of Washington in Seattle, where he remained on the faculty for 17 years.